Step 1: Get access to the infected hard drive (directly). If your infected machine is a laptop, then you will have to either take it apart on your own or lookup how to take that perticular laptop apart on the internet. Google is handy for this… 1 thing to notice, is that sometimes laptops have easy access to the hard drive under those handy access panels on the bottom of the laptop (usually require the removal of 1 screw). I have a fujitsu that gives easy access to the hard drive if you slide the cd rom drive out. If your machine is a desktop, all desktops are very similar. It usually involves removing the 2 screws opposite all your connectors on the case. Some even have a handy knob you can unscrew with your hand. Then removing cover usually involves pulling towards the rear of the machine, but sometimes it involves lifting from the back. Play with it, if you cannot get it apart, look it up online and see how it comes apart.
Once your cover is off, do the following: Plug the computer into the wall and then put on your anti-static strap. Make sure you are plugging it into a grounded outlet. If you don’t know what a grounded outlet or how to test for one, then see http://answers.yahoo.com/question/index?qid=20090219215753AAE5miM . The reason for this step, is a grounded outlet allows static electricity to flow to ground (safely away from the system). Now hook the clip side of your grounding strap to the back of the computer (any metal spot will do, but it is recommended to use the back of the power supply). This allows static electricity to flow from you to the grounded case, which allows the static to flow safely to ground. The case can handle lots of electricy, the sensitive electronics inside it cannot. Many people have different opinions as to grounding proceedures, so if you have a preferred way of doing it, then go for it. There is a pretty good article here: http://www.pcworld.com/article/82184/avoid_static_damage_to_your_pc.html
Now find the hard drive. It should look something like this: http://images.google.com/images?q=hard%20drive&rls=com.microsoft:en-us&oe=UTF-8&startIndex=&startPage=1&um=1&ie=UTF-8&sa=N&hl=en&tab=wi . Usually it is just a few screws to remove it, but sometimes they can clip in or slide in with adapters, depending on who designed your system. Unplug it and remove it as necessary. DO NOT DROP YOUR HARD DRIVE… THEY HAVE SENSATIVE PARTS INSIDE AND DROPPING THEM OFTEN KILLS THEM, AND THEN YOU DON’T HAVE TO WORRY ABOUT THE VIRUS :)